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However, pathogenesis of macular degeneration is a complex interaction between genetics, environment and lifestyle, and presence of unfavorable genetic factors doesn't necessarily predict progression to disease. The American Academy of Ophthalmology practice guidelines do not recommend laser coagulation therapy for macular degeneration, but state that it may be useful in people with new blood vessels in the choroid outside of the fovea who don't respond to drug treatment. Macular degeneration typically occurs in older people. A practical application of AMD-associated genetic markers is in the prediction of progression of AMD from early stages of the disease to neovascularization. There are multiple layers that make up the retina, and in geographic atrophy, there are three specific layers that undergo atrophy: the choriocapillaris, retinal pigment epithelium, and the overlying photoreceptors. Similar symptoms with a very different etiology and different treatment can be caused by epiretinal membrane or macular pucker or any other condition affecting the macula, such as central serous retinopathy.

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Macular degeneration by itself will not lead to total blindness.

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Because these blood vessels are abnormal, these are also more fragile than typical blood vessels, which ultimately leads to blood and protein leakage below the macula. The Journal of Biological Chemistry. Paralytic strabismus Ophthalmoparesis Chronic progressive external ophthalmoplegia Kearns—Sayre syndrome. It is a capillary network that provides nutrients to the retinal pigment epithelium.

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